A new way of conducting research.

Digital Health Trial: Can Artificial Intelligence Predict the Optimal Supplements for Crohn 's Disease and Ulcerative Colitis?

Inflammatory Bowel Disease (IBD) is a chronic disease of the gastrointestinal tract, thought to be due to an abnormal response of the body 's immune system. According to The Centers for Disease Control and Prevention (CDC) more than 3 million people in the US are affected by IBD.

The two most common types of IBD are Crohn 's Disease and Ulcerative Colitis. Each have some similar elements but are unique as well. Treating IBD can require both medications and surgery, but dietary changes and supplements can also play an important role.

Some people may follow specific diets for Crohn 's Disease or Ulcerative Colitis, but there are still many unknowns about what works best for individuals.


Supplements also play an important role in helping individuals manage their Crohn 's or Colitis. These can range from probiotics, to teas, to different herbal compounds, a large number of possibilities making it hard to know what works. Another challenge is that one supplement type may actually be made up of several active ingredients and it can be hard to understand how all of these work together. IBD is complex and we are still uncovering new information, such as the role of the gut microbiome. Gut microbes (bacteria) help us digest foods and supplements but If the digestive tract is damaged, however, it may lead to the growth of different types of microbes so it is a very complex picture.


Understanding the relationships between different supplements and microbes with IBD is a big data challenge that artificial intelligence (AI) is great for. AI can help find patterns through very large volumes of data that we have not been able to do until very recently. This digital health trial is the first framework for establishing how AI can help predict which supplements may be optimal for people suffering with inflammatory bowel disease, a chronic condition with no easy answers.


By collecting data points around the disease and especially the relationship between supplements, gut microbiome and other “omics” like environment or physical activity and applying artificial intelligence (AI) technology to the data, there is a chance to identify common patterns among those correlations and gain deeper insights on the disease.

The Medical Research Companion

doc.ai is a platform that helps you collect and manage your health data securely in one place and and through your participation accelerate medical research with the power of artificial intelligence. Digital Health Trials are a new way of conducting research to develop more precise and predictive models for healthcare management.

Meet Sean Ahrens,

Founder Crohnology.com, patient-centered information sharing network for people with Crohn 's and Colitis.

Patient advocate, Advisor at doc.ai

I’ve fought a battle against Crohn’s disease for nearly 20 years, and if there’s one thing I’ve gotten to know well, it is the untapped power of patients. You and I are sitting on top of a massive wealth of information that could advance medical research for our conditions, Crohn’s and Colitis. That information is how our disease responds to our daily lives — the food and supplements we eat; the treatments, medicines, supplements we take; and the actions and exercise that we do. Doctors and medical researchers don’t see these things. Which means 99% of our experience is not seen. I’m excited to have you together with me and other patients to turn this statistic on its head. I’m excited to see what we, together, can discover that may massively improve our lives and the lives of other patients. Thank you for being a part of this.
Dr. Shekhar Challa

Gastroenterologist, Kansas Medical Center

Principal Investigator for Digital Health Trial "Can Artificial Intelligence Predict the Optimal supplements for Crohn 's Disease and Ulcerative Colitis?"

When I began practicing 31 years ago, our options of treating IBD were limited. This certainly is not true today-we have several new options to treat IBD now. I am convinced that Artificial Intelligence (AI) is the next frontier in helping us open new doors as to how we look at treating IBD. I am proud to be part of the doc.ai team to explore the role of supplements in IBD.
Protocol: DOC-003-2018

Using Artificial Intelligence to predict the most optimal food supplements for patients with Inflammatory Bowel Disease based on their phenome, physiome, exposome, and microbiome.

Participant Activity

To understand changes in your health, besides a brief initial survey, we will ask participants to complete a daily survey of symptoms and supplements. A few weeks into the study participants will receive a uBiome gut microbe test. This will enable researchers to better predict patterns around supplements, microbes, and inflammatory bowel disease.

Contact us at predictsupplements@doc.ai.

Get in touch

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